Giants vs. Bills Odds, Preview, and Best Bets for NFL Week 6

SBNY » Giants vs. Bills Odds, Preview, and Best Bets for NFL Week 6

The nightmare rolls on for the New York Giants, but the season of hope continues for the Buffalo Bills.

The Giants are coming off of a loss to the Dolphins where New York had no chance at any point. Daniel Jones left the contest in the second half after a sack. Plus, Darren Waller and Daniel Jones did not practice on Wednesday.

The defense for New York also put forth a subpar performance against Miami. For the third time this season, the Giants gave up 30 points or more. The D, however, did account for the only touchdown for Big Blue. New York could not handle the speedsters for the Dolphins in Tyreek Hill, De’Von Achane and Jaylen Waddle. Miami poured out 524 total yards of offense, and New York had no answer.

Bills Have Uneven Performance in London vs. Jags

On the other side, the Bills are coming off of a tough loss to the Jacksonville Jaguars 25-20 last week in London. Buffalo was down 11-7 for a large majority of the game, and played catch-up down the final stretch in the fourth quarter.

The big story from this game for Buffalo is that it is extremely thin on depth on the defensive side of the ball. Linebacker Matt Milano suffered a lower-body injury and will miss the rest of the season. Additionally, defensive lineman DaQuan Jones suffered a pectoral injury and will also miss the remainder of the NFL season. The Bills signed linebacker AJ Klein, who has appeared in 37 games for the Bills over the last three seasons, off the practice squad. Even so, the losses of Milano and Jones put a dent in this defense.

The Bills have still managed to put up over 30 points in three of the last four weeks. This an explosive offense with Josh Allen as the signal caller and Stefon Diggs as his number one target. Gabe Davis has scored a touchdown in each of the last four games.

In an AFC versus NFC matchup, one that features two teams in the tri-state area, there are certainly prop bets for fans to take. With both teams going in different directions, here are the best ones to place.

Latest Giants vs. Bills Odds at NY Sportsbooks
Bet $5, Get $150 in Bonus Bets
4.5 rating

GIANTS VS. BILLS ODDS: Take Buffalo (-14) as Heavy Favorites

A two-touchdown line can be scary for bettors, but here is a fact that is important to remember: the Giants have not covered a spread this season. The singular victory for New York in 2023 came in Week 2, when it had to climb back from a 21-point deficit to take down the Arizona Cardinals, who also sit at 1-4.

All four of the Giants’ losses have been ugly. The first was a 40-point blowout, then fell to the 49ers by 18 points in Week 3. New York lost to the Seahawks by 21 on Monday Night Football in Week 4 and then got handled by the Dolphins. Three of those losses have happened on nationally-televised games, and this matchup is set for Sunday Night on NBC.

On the other hand, the Bills’ wins have always been big. Buffalo has won by more than 14 in all three victories, and scored at least 35 points. The Bills offense is a wagon.

It is fair to expect the Bills to win this game over the Giants, but it is a matter of how much Buffalo will win by. Expect this to be a multiple score game in favor of the Bills and take this prop bet on DraftKings.

New York Giants vs. Buffalo Bills Totals Odds: Go Under 44.5

The Giants offense is not one that can put up points in bunches. New York has failed to score an offensive touchdown in the first half of a contest this season. There’s also a chance that starting quarterback Daniel Jones does not play and backup Tyrod Taylor steps in as the signal caller. Plus, this offense without Saquon Barkley is at a disadvantage, and it might be in that position for a third-straight week.

The aspect of this bet that may leave fans cautious is that the Bills can put up a lot of points. Buffalo even put up 48 against the Dolphins in Week 4. If a game is so lopsided, it’s difficult to expect the Giants to give up 45 points in this game. It’s not a glamorous bet, but it’s the right one to place with these odds. Take this prop on FanDuel.

Bet Week 6 of the 2023 NFL season at NY Sportsbooks
Bet $5 Get $150 in Bonus Bets
If Your Bet Wins
5.0 rating
Top Sportsbooks 2023
5.0 rating
Bet $5 Get $150 in Bonus Bets
If Your Bet Wins
4.3 rating
Get Up To $100
In Bonus Bets!
Bonus Code: Sports
3.3 rating
First Bet Offer Up To $1500

BetMGM Sportsbook Welcome Offers Halted in the state of NY! But Available In NJ.
4.8 rating
Bet $50
Get Up To $1000 Back In Bonus Bets
On Caesars
4.5 rating
Bet $5, Get $150 in Bonus Bets