New York enters Week 17 with the possibility of clinching a playoff berth with a win over Indianapolis. The Giants stand as six-point favorites over the Colts in the betting odds.

As the NFL opens its penultimate slate of regular season games, playoff races continue to heat up throughout the league. Although New York took a tough loss on the road last week, the G-Men still stand in favorable position for a postseason run. 

The New York Giants (8-6-1, 11-4 ATS) took a tough loss on the road last week, falling to the Minnesota Vikings 27-24 on a 61-yard field goal as time expired. The G-Men pushed one of the NFC’s elite teams in their home stadium, which gives New York hope with a potential Wild Card road game down the line. Despite the loss, the Giants actually hold their playoff destiny in their own hands. 

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Here’s a look at the best betting odds for this matchup between the Giants and Colts in Week 17.

Best Betting Odds for New York Giants vs Indianapolis Colts

SpreadMoneylineTotal
Colts Best Odds+6.0/-110 (See the Odds on Caesars)+200 (See the Odds on DraftKingsOver 38.5/-110 (See the Odds on BetMGM)
Giants Best Odds-5.5/-115 (See the Odds on FanDuel)-240 (See the Odds on PointsBetUnder 38.5/-110 (See the Odds on BetRivers)

The opening lines for this game set the Giants as 3.5- to 4-point favorites, but action on New York’s side quickly pushed that line to 6.0 across the board. The Colts have nothing to play for at this point, and a win punches a playoff ticket for the G-Men. It helps that New York’s been one of the best against the spread teams this season.   

The point total for this contest started at 41 this week. Since then, though, it’s ticked down at each sportsbook, landing between 38.5 and 38 heading into the weekend. This makes it the third-lowest total on the board in Week 17. 

NFL Week 17 Preview: New York Giants vs Indianapolis Colts

Last week, the Giants looked good against Minnesota on the road. Daniel Jones threw for a season-high 334 passing yards and Saquon Barkley registered 6.0 yards-per-carry and scored the game-tying touchdown late in the loss. Now, the G-Men come home to face a reeling Colts squad. The Giants need a win in either of the final two games in order to snap a playoff drought that’s extended since 2016. 

The Indianapolis Colts (4-10-1, 6-9 ATS) had high hopes heading into 2022, having acquired Matt Ryan at quarterback. But Indy flopped this season and fired head coach Frank Reich as a result. Ryan’s been benched for the second time this season, and Indy turns to journeyman Nick Foles, who didn’t look good in his first start of the season last week. Foles threw three interceptions and was sacked seven times. 

The Colts rank 31st in scoring (16.5 points-per-game) and 28th in total offense (309.9 yards-per-game). Indy is one of four teams eliminated from playoff contention in the AFC, and they’ve lost five games in a row. At minus-109, Indy sports the NFL’s worst point differential so far this season. 

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Betting Trends Affect Giants, Colts Odds 

Several betting trends affect the odds in this matchup between the Giants and Colts. While these teams don’t play very often, the road team has found success in this series. Away teams hold a 4-1 mark against the spread in the last five matchups. 

That said, New York enters 4-1 against the spread in its last five games overall, and 20-9-1 against the spread in its last 30 games versus teams with a losing record. 

Considering the nature of these two offenses, the Under might be the best play for this game. The Giants average 20.4 points-per-game at home and the Colts average 15.6 points-per-game on the road. 

New York’s seen the Under hit in 15 of its last 20 home games, and Indy’s seen the Under in 15 of their last 20 overall. The Over is 4-1 in the last five meetings between these clubs, but the Colts have seen the Under hit twice as much as the Over so far this season (10-5). 

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