The New York Giants start the 2022 NFL season in Tennessee versus the Titans. Here’s a look at the best betting odds for that contest.

The New York Giants stand on the precipice of a new era in the Big Apple. New head coach Brian Daboll enters the fray with an offensive mindset that should help elevate the G-Men’s inept scoring unit. The first test of the 2022 NFL season comes in Tennessee, where the Giants face the Titans and stand as underdogs in the betting odds. 

Daboll comes to New York following a successful run as offensive coordinator for the Buffalo Bills. With Josh Allen at the helm, Daboll helped orchestrate that finished third in the NFL with 28.4 points-per-game and fifth with 381.9 yards-per-game of total offense. He’ll embark on his first season with Daniel Jones hoping to recreate those figures.

Here’s a look at the best betting odds for this NFL Week 1 bout between the New York Giants and Tennessee Titans. 

Best Giants-Titans Betting Odds

The betting odds for this Giants-Titans contest opened with Tennessee as minus-6.5 favorites. But early action on the Giants narrowed those odds to 5.5 at most sportsbooks. The total for this game held steady at or near 43.5. 

Giants Best Odds+5.5/-107 (PointsBet)+215 (DraftKings)Over 43.5/-110 (BetRivers)
Titans Best Odds-5.5/-110 (Caesars)-238 (FanDuel)Under 43.5/-105 (DraftKings)

At BetMGM, bettors can hedge the Titans against the spread with a Winning Margin wager with +320 odds for Tennessee to win over the Giants by 1-6 points. BetMGM also lists a wager for New York’s total points scored at 17.5, with the Over seeing -125 odds and the Under seeing +100. The Giants averaged 25 points-per-game this preseason. 

NFL Week 1 Preview: New York Giants at Tennessee

The Giants enter this game against the Titans as the underdog in the betting odds, based largely on last year’s 4-13 performance. New York pinned its hopes on Jones this season, but Tyrod Taylor provide a capable backup. The G-Men look for Saquon Barkley to resume his role as the lead back, while fielding a wideout group with plenty of potential in guys like Kadarius Toney and rookie Wan’Dale Robinson.

The Titans revamped their receiving corps, adding Robert Woods and drafting Treylon Burks, trading away A.J. Brown. Tennessee hopes All-Pro running back Derrick Henry returns to his pre-injury form behind quarterback Ryan Tannehill. The Titans defense took a blow recently when Pro Bowl pass rusher Harold Landry tore his ACL in practice. 

New York sees several key players on the injured list ahead of this ballgame, including rookie first-rounder Kayvon Thibodeaux, who participated in drills this week but remains uncertain for Week 1. The G-Men will be without guard Shane Lemieux and other offensive linemen for this contest. 

Betting Trends Affect Giants, Titans Odds 

Several betting trends affect the odds entering this NFL Week 1 matchup between the Giants and Titans. New York hasn’t won a season opener since 2016, going 0-5-1 against the spread in that stretch. The Titans, though, have also been slow starters, going 1-5 against the spread in their last six season openers. 

The Titans enter this one 9-12-1 against the spread as home favorites with Mike Vrabel as head coach and 23-9 straight up in their last 32 contests as home favorites. Tennessee also enjoys a 6-1 mark against the spread in its last seven games against the Giants. 

Giants quarterback Daniel Jones enters this contest 11-4 against the spread in his career as a road underdog. But New York finished last season on an 0-6 ATS skid and failed to cover in each of their last five road games. 

Last season, the Giants saw the Under hit in 11 of their 17 games, while Tennessee saw the Under 10 times in 18 tries. The Under is 5-1 in New York’s last six season openers and 5-0 in the Tennessee’s last five home games.

Top Sportsbooks 2023
5.0 rating
Bet $5 Get $150 in Bonus Bets
If Your Bet Wins
4.3 rating
Get Up To $100
In Bonus Bets!
Bonus Code: Sports
3.3 rating
Bet $5 Get $150 in Bonus Bets

BetMGM Sportsbook Welcome Offers Halted in the state of NY! But Available In NJ.
4.8 rating
Bet $50
Get Up To $1000 Back In Bonus Bets
On Caesars
4.5 rating
No Sweat First Bet up to $1,000