The Buffalo Bills enter their NFL Week 2 matchup on Monday Night Football seeing favorable betting odds against their AFC rival, the Tennessee Titans.

The Buffalo Bills made a national statement in the 2022 NFL season opener by dominating the Los Angeles Rams. Despite the hype, Buffalo lived up to their top billing last Thursday night. Following the impressive 31-10 victory, the Bills enter their Week 2 matchup with the Titans as favorites in the betting odds. 

After Week 1’s win, the Bills saw their futures odds shorten across the board. The biggest moves for the Bills here came at both FanDuel and PointsBet, where the team held +650 odds recently. BetMGM shorted from +600, as did Caesars and DraftKings. 

Here’s a look at the best betting odds for the Bills and Titans grudge match on Monday Night Football. 

Best Betting Odds for Bills vs Titans 

Titans Best Odds+10/-110 (Caesars)+400 (PointsBet)Over 48/-110 (DraftKings)
Bills Best Odds-9.5/-110 (PointsBet)-435 (BetRivers)Under 48.5/-113 (BetRivers)

Bettors saw an opening line spread of 10 points at most sportsbooks. The Look Ahead line for this Buffalo-Tennessee battle featured the Bills as 7.5-favorites in the betting odds. But after the Titans lost to the New York Giants in Week 1, sportsbooks faded last season’s top seed in the AFC. 

The total for this matchup opened at 51 but has since trended down from there. Most sportsbooks place it between 48 and 48.5 at this point. Early action seems to favor the Over, and most sportsbooks have reported the majority of the handle has backed Buffalo so far. 

NFL Week 2 Preview: Buffalo Bills vs Tennessee Titans

Josh Allen completed 26 of 31 passes for 297 yards and three touchdowns. While he did throw two interceptions, he added a team-high 57 rushing yards and a touchdown on the ground as well. This performance goosed Allen’s MVP odds almost across the board. And in five career Monday Night Football games, Allen has thrown 14 touchdown passes to just two interceptions, for a 110.8 QB Rating. 

Perhaps the most impressive part of Buffalo’s win in Week 1 was the performance of its defense. The Bills defensive line dominated the contest, registering seven sacks. Buffalo’s D also intercepted three passes. 

The Titans had no answer for Saquon Barkley in Week 1 and Derrick Henry still seemed to be shaking off the rust from last year’s serious injury. Couple that with the fact that Josh Allen already put his stamp on the MVP race, the Bills enter this one as significant favorites. 

Tennessee coughed up a 13-0 halftime lead against the Giants in Week 1. Henry totaled 82 rushing yards on 21 carries and the Titans struggled to convert on third down (3-for-11). Tennessee’s defense did register five sacks, though. 

Last season, the Titans beat Buffalo 34-31 in Week 6, with Henry racing to 143 total yards and two touchdowns. AJ Brown chipped in with seven catches and 91 yards, but he’s playing in Philadelphia now and Henry’s still working his way back to form. Going back to the start of the 2019 season, Tennessee’s just 4-9 when Henry registers 82 rushing yards or fewer. 

The Bills allowed just 52 rushing yards in Week 1 and limited opponents to 80 rushing yards or fewer nine times last season. 

The injury report for this game sees a couple of key contributors for Buffalo’s defense on it. CB Dane Jackson (knee), DT Ed Oliver (ankle), and DT Tim Settle (calf) all missed practice this week, leaving their availability for Monday night in question. 

Betting Trends Affect Bills, Titans Odds 

Some of the betting trends back the Bills’ favorable odds versus the Titans. What’s more, the Bills hold a serious rest advantage, having played last Thursday.

Buffalo’s 5-1-1 against the spread in their last seven games, and 3-0-1 against the spread in their last four home contests. Tennessee, meanwhile, enters 3-7 against the spread in their last 10 games. 

The Bills enter this contest 6-2-2 against the spread when favored by 10-points or more dating back to 2016, including a 5-1-1 mark last season. Buffalo’s 4-0-1 against the spread in its last five games as the betting favorite. The Bills are 15-9-3 against the spread and 22-5 straight up as home favorites under head coach Sean McDermott. 

Dating back to 2015, Buffalo’s 3-4-1 against the spread and 2-6 straight up on Monday Night Football. Tennessee, meanwhile, is 8-2 against the spread in their last 10 Monday games.

The Over went 3-6 in Buffalo home games last season. The Under has gone 4-3-1 in the Bills’ last eight Monday Night Football games. For the Titans, the Under hit in four of their last five Monday contests. 

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