Buffalo looks to build on recent playoff success and finally break through to the Big Game. Here’s a look at the betting odds as the Bills finish the preseason vs the Panthers.

The Buffalo Bills cruised to their second win of the preseason with a 42-15 victory over the Denver Broncos last week. Buffalo’s offense looked all the more efficient against the Broncos thanks in large part to a boost from Bills starters. Now, the Bills, carrying favorable betting odds, hope to close the preseason with a win against the Panthers.

Buffalo sees talent and depth across the board, and that was on display last week as MVP frontrunner Josh Allen hit all three of his pass attempts for 45 yards and a score. The Bills carved up Denver’s defense, scoring touchdowns on their first six drives. 

While wagering on preseason games can be a tricky proposition, the betting odds for this Bills-Panthers contest provide potential value. 

Bills, Panthers Preseason Betting Odds

A look at the betting odds ahead of the Bills’ preseason finale versus the Carolina Patriots indicates Buffalo enters as the underdog. Preseason trends feature a wide variance for bettors, as favorites covered 53.3 percent of the time in 2021, but underdogs covered 60.8 percent of the time in 2019. (There was no preseason in 2020.)

Bills Best Odds+6/-110 (FanDuel)+200 (PointsBet)Over 42/-110 (BetMGM)
Panthers Best Odds-6/-110 (Caesars)-240 (DraftKings)Under 42.5/-105 (FanDuel)

Several New York sportsbooks carry lines and betting odds for this preseason, and it’s no surprise the Bills sport the shortest Super Bowl odds for 2022.

Bills Preseason Preview Week 3

Josh Allen got his first taste of preseason action last week, finishing 3-for-3 with a touchdown and flashing his elusiveness in the pocket. Although he only played six downs, Allen looks ready for the regular season. That said, Allen admits there are aspects of his game he hopes to improve this season. 

Whether or not Allen plays in the preseason finale remains a question, but it’s not one that concerns the Bills starting quarterback. 

Last week’s 42-point outburst proved to be Buffalo’s second 40-point preseason explosion in the last two seasons. Prior to that, the NFL hadn’t seen a 40-point performance in exhibition since 2018. Buffalo’s 42 points was the franchise’s third-highest scoring preseason affair ever. 

Buffalo racked up 208 rushing yards on 27 carries, with Raheem Blackshear (11 carries, 69 yards, two TD) and Duke Johnson (15 carries, 64 yards, two TD) doing most of the damage. Those two continue to fight for a roster spot and should get plenty of run in this game. 

At this point, most of the Bills’ major position battles seem settled. It won’t be a surprise if head coach Sean McDermott rests most, if not all, of the starters. That assumption tilts the betting odds for this Bills ballgame in favor of the Panthers.

That said, the Bills sport a much deeper roster and seem like a more favorable play here getting six points against the Panthers in the betting odds. Bills fans also see favorable odds for betting specials at FanDuel.

Preseason Trends Affect Betting Odds for Bills vs Panthers

The Bills see themselves as underdogs in the betting odds against the Panthers this week. But Buffalo’s been one of the most successful preseason teams in the league of late. The Bills enter on a 10-game preseason winning streak, second only to the Baltimore Ravens (22). The team is 12-5 in exhibition games under McDermott. 

What’s more, the Bills have won nine consecutive preseason games as underdogs.

The preseason trends affect this Bills-Panthers game because Buffalo’s been so dominant of late. The Bills enter 10-0 against the spread in their last 10 exhibition matchups, whereas Carolina’s only 7-5-1 against the spread in their last 13 preseason games. 

The Over has hit in eight of Buffalo’s last 10 preseason games, and 11 of the Panthers’ last 17. Carolina’s only 5-4-1 against the spread in their last 10 preseason games as the favorite. 

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