The Buffalo Bills look to build on recent playoff success and finally break through to the Big Game. The Super Bowl favorites entering 2022 see solid betting odds.

The Buffalo Bills opened their preseason slate with a 27-24 victory over the Indianapolis Colts last week, with bettors cashing in on +1 odds. Now, bettors turn their attention to this Week 2 preseason matchup between the Bills and Broncos, zeroing in on the best betting odds.

The Bills offense looked shaky without Josh Allen and some of the other stars versus Indianapolis in the preseason opener. That said, the team overcame five turnovers and managed a come-from-behind victory to extend its preseason winning streak to nine straight. 

It’s no surprise the Bills sport the shortest Super Bowl odds for 2022. Buffalo sees talent and depth across the board, and according to head coach Sean McDermott, the starters will play a “healthy amount” versus the Broncos this weekend. 

While wagering on preseason games can be a tricky proposition, Bills fans and bettors see potentially valuable betting odds for this contest. 

Bills, Broncos Preseason Betting Odds

Thursday’s news that Bills starters will see the field pushed the betting odds even further in Buffalo’s favor. The offense looked stagnant at times versus the Colts, but now MVP frontrunner Josh Allen will be under center for a period of time. 

Broncos Best Odds+6/-110 (Caesars)+210 (FanDuel)Over 41.5/-110 (DraftKings)
Bills Best Odds-5.5/-110 (BetRivers)-225 (DraftKings)Under 42/-110 (FanDuel)

Adding Allen and the other Bills starters to the mix not only moved the spread and moneyline betting odds at most sportsbooks, but also the over/under total. Last week, Buffalo’s starting quarterback Case Keenum struggled, throwing two interceptions and losing a fumble. Those errors seem less likely to occur with Allen at the helm. 

There’s no official word yet from Broncos camp as to the availability of key starters on Denver’s end, including starting quarterback Russell Wilson. The Broncos won their preseason opener 17-7, but scored all their points in a second quarter flurry and looked largely sluggish outside of that run. 

Bills Preseason Preview Week 2

While most of the starters got the night off, rookies flashed in their first NFL opportunities, including Boogie Basham, Christian Benford, Kaiir Elam, and Khalil Shakir. Even rookie punter Matt Araiza impressed with his 82-yard boot during the game. News that the starters will play pushed the Bills betting odds for this contest, but it also will limit the opportunities for these rookies. 

Some position battles to keep an eye on during this game include wide receiver, cornerback, and linebacker. Rookies put their mark on these battles last week, so it’ll be interesting to see if the veterans in the mix can regain their footing. 

Following his performance last Saturday, Shakir looks like a lock to make the roster and perhaps contribute at wide receiver. Veterans Jamison Crowder and Jake Kumerow, however, each provide veteran experience, but need to bounce back from poor preseason performances thus far. 

At cornerback, Tre’Davious White remains on the mend and Dane Jackson sat out last week, leaving the rookies Elam and Benford to man the outside. Both flashed in their time on the field last week and need to do so again to establish potential roles going forward. 

Rookie linebackers Terrel Bernard and Baylon Spector also stood out with their performances against the Colts, but they’ll need to improve in pass coverage to ensure roster spots and defensive roles. 

Preseason Trends Favor Bills Betting Odds

With their win last week, Buffalo pushed their preseason winning streak to nine in a row, the second-longest current streak in the NFL behind only the Baltimore Ravens, who’ve won 21 consecutive preseason contests.  

Some of the trends tilt in favor of the Bills betting odds for this contest. Buffalo’s 5-0 against the spread and 4-1 straight up in its last five games versus the Broncos. The Bills covered as a one-point underdog last week. Bills fans also see favorable odds for betting specials at FanDuel.

As far as the total is concerned, the Bills have seen the over hit in six of their last eight games. The Broncos, meanwhile, have seen the under hit in 15 of their last 20.

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